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43,44,45,46 Other notable conditions frequently excluded were a history of cancer within 5 years (52%), immunocompromised state (45%), and vascular disease of the lower extremity (42%)

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The British National Formulary (BNF), the British Society of Haematology Guidelines, NHS Clinical Knowledge guides, Integrated Care Board guidance notes such as this one from NHS Cambridgeshire and Peterborough, Vitamin B12 full guidance

After this point, both peptide degradation and bacterial contamination risk increase beyond acceptable thresholds, even with bacteriostatic water as the diluent